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Heparins are highly-sulfated glycosaminoglycan derived from porcine or bovine mucosal tissues. Native heparin has a molecular weight range of 3 - 40 kDa, while most commercial preparations are 12-15 kDa. Heparin is composed of variably-sulfated disaccharide repeating units, predominantly a 2-O-sulfated iduronic acid and 6-O-sulfated, N-sulfated glucosamine, IdoA(2S)-GlcNS(6S). They are used as injectable anticoagulants or for anticoagulant surface in medical devices. Low molecular weight heparins have been introduced more recently as effective therapeutics.
see HEP1 |
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Low-Molecular Weight Heparins in Prophylaxis and Therapy of Thromboembolic Diseases, H. Bounameaux, ed., Marcel-Dekker, New York, 1995; Biomimetic Polymers, Linhardt, R. J, Loganathan, D., Plenum Press, New York, 1990; Ann. NY Acad. Sci., 556, 468, 1989.
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