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Cyclodextrins are cyclic molecules with six or more a-1,4-linked D-glucose units that are well known for their ability to complex various organic molecules. The core of the cyclodextrins is hydrophobic and offers a means of enhancing drug bioavailability and the solubility of poorly water soluble materials, such as lipophilic drugs. Cyclodextrins can mask or deliver odor and taste, or reduce drug side effects. Recently, it has been shown that even certain polymers, e.g., poly(ethylene oxide)s, can form complexes with cyclodextrins. see CD1 |
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Chem. Rev., 98, 1743, 1998; ibid., 98, 1875, 1998; ibid., 98, 2045, 1998; Intl. J. Pharmacol., 29, 73, 1986; Intl. J. Pharmaceutics, 8, 380, 1991; Cyclodextrin Chemistry, M. L. Bender and M. Komiyama, Springer, Berlin, 1978; J. Pharm. Sci., 88, 302, 1999; J. Pharm. Sci., 86, 147, 1997; Pharm. Res., 14, 556, 1997; Antisense Res. Rev., 5, 185, 1995.
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