| The introduction of acidic function through oxidation or carboxymethylation transforms many insoluble polysaccharides to soluble materials that are also useful as reactive intermediates for conjugation to other molecules via amide, amine, ester or other stable linkages. Oxidized glycans have found many biological applications, including as hemostatic materials (1), biosorbable surgical lubricants, threads and networks (2, 3, 4), blood reducing agents (5), drug carriers (6), and enzyme carriers (7). Nonbiological applications of oxidized glycans include their use as ion exchange or metal adsorbents (8), detergent builders (9), deoderizers (10) and resol cross-linkers (11). Oxidized cellulose has been used as a substrate for graft copolymerizations (12). For additional products, see listings under ANIONIC DERIVATIVES [152] |
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1.J. Biomed. Mater. Res., 21, 173, 1987. 2. U.S. Pat. 4,668,224, 1987. 3. German Pat., 3,108,163, 1982 (CA 97 22301). 4. Eur. Pat., 303,496, 1989 (CA 111 160312). 5. USSR Pat., 430,857, 1974 (CA 82 21825f). 6. USSR Pat., 389,794, 1973 (CA 80 137175g). 7. Acta Biol. Med. Ger., 33 15, 1974. 8. J. Appl. Polym. Sci., 40, 1601, 1990; J. Appl. Polym. Sci., 29, 2289, 1984. 9. U.S. Pat., 3,784,475, 1974. 10. U.S. Pat., 3,868,955, 1975. 11. Jap. Pat., 81 81,358, 1981 (CA 96 36232y). 12. J. Appl. Polym. Sci., 35, 885, 1979.
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